Which surrogate endpoints are valid for assessing thrombotic tendency?
| Autor: | Fredd, Stephen |
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| Předmět: | |
| Zdroj: | American Journal of Clinical Nutrition; Oct1992, Vol. 56 Issue 4, p814S-814S, 1p |
| Abstrakt: | The article reports that decreased hematocrit or platelet count is used as surrogate endpoint to identify thrombotic tendency in polycythemia patients. Topics discussed include requirement of hypercoagulability, vascular injury and stasis for clinically relevant thrombosis, occurrence of asymptomatic protein C deficiency at a high frequency in blood donors, and efficacy of long-term prophylactic oral anticoagulation therapy in preventing risk of bleeding. |
| Databáze: | Complementary Index |
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