| Autor: |
Wu, Chang-you, Kirman, Joanna R., Rotte, Masashi J., Davey, Dylan F., Perfetto, Steve P., Rhee, Elizabeth G., Freidag, Brenda L., Hill, Brenna J., Douek, Daniel C., Seder, Robert A. |
| Předmět: |
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| Zdroj: |
Nature Immunology; Sep2002, Vol. 3 Issue 9, p852, 7p |
| Abstrakt: |
We studied here the long-term maintenance of distinct populations of T helper type I (T[SUBH]I)-lineage cells in vivo and found that effector T[SUBH]I cells, defined by their secretion of interferon-γ (IFN-γ), are short-lived and do not efficiently develop into long-term memory T[SUBH]I cells. In contrast, a population of activated T[SUBH]I-lineage cells that did not secrete IFN-γ after primary antigenic stimulation persisted for several months in vivo and developed the capacity to secrete IFN-γ upon subsequent stimulation. These data suggest that a linear differentiation pathway, as defined by the transition from IFNγ-producing to resting memory cells, is relatively limited in vivo and support a revised model for T[SUBH]I memory differentiation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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