Oral Surgery In Severe Thrombocytopaenia Patients: A Case-Control Comparison of Platelet Concentrate Versus Platelet Transfusion.

Autor: Cocero, Nadia, Bergamasco, Laura, Mozzati, Marco
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Zdroj: International Dental Research; Aug2012, Vol. 2 Issue 2, p33-36, 4p
Abstrakt: Aim: Surgical treatment of patients with severe thrombocytopaenia (<50,000 platelets/μL) is a major problem for dentists due to an increased risk of bleeding. To reduce post-extraction haemorrhage, we tested a new approach using a platelet concentrate and compared its outcomes with those of routine platelet transfusion. Methodology: Sixty-six patients with a platelet count between 29,000 and 46,000/μL were included in the study. Each patient was to undergo at least two sessions for the extraction of teeth; in one session the patients received a platelet transfusion before the extraction and in the other the post-alveolar sockets were treated with Plasma Rich in Growth Factors (PRGF). Patients were evaluated after 0.4, 1, 3 and 7 days to assess bleeding and haematoma. Results: Patients treated with PRGF consistently exhibited a statistically significant reduction in post-extraction bleeding, hematoma and need for re-intervention. There is ample evidence that application of PRGF in the post-alveolar socket markedly reduced the risk of haemorrhage and associated complications in all patients. Conclusion: PRGF concentrate is recommended for the treatment of thrombocytopaenic patients due to its remarkable ability to stimulate healing while greatly reducing side effects, such as bleeding and haematoma. [ABSTRACT FROM AUTHOR]
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