On the possibility of determination of stereological characteristics of interactions of biological micro objects with nanoparticles based on analysis of 2-dimensional images of cytological and histological specimens.

Autor: Zhukotsky, A., Baranov, V., Karnaukhov, A., Yakubova, N., Karnaukhova, E., Katkova-Zhukotskaya, O., Rubchenkova, S., Karnaukhov, V.
Zdroj: Biophysics; Sep2013, Vol. 58 Issue 5, p664-668, 5p
Abstrakt: In this article the method for studying 3-dimensional (stereological) characteristics of interactions of biological micro objects with nanoparticles on a basis of morphodensitometry analysis of standard 2-dimensional images of cytological and histological specimens is proposed. The performance of the task of determining the distance from registered nanoparticle to the center of the nucleus of the cell is described in detail. It is shown that using specific nanoparticles the results obtained may find application in science and diagnostics. Furthermore, it is possible to employ these results in nanotoxicology, in particular for determination of quantity characteristics of translocation of nanoparticles of different types in biological structures. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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