DNA replication and chemotherapy.

Autor: Hubscher, Ulrich, Spadari, Silvio
Předmět:
Zdroj: Physiological Reviews; Apr94, Vol. 74 Issue 2, p259, 46p, 14 Diagrams, 5 Charts
Abstrakt: Examines the importance of deoxyribonucleic acid (DNA) replication to physiology and chemotherapic drugs. Model systems to study eukaryotic DNA replication; Sources and origins of DNA replication; Proteins and enzymes at the replication fork of DNA synthesis; Overview of deoxyribonucleotide triphosphates biosynthesis; Usefulness of inhibitors of DNA replication enzymes to clinical medicine.
Databáze: Complementary Index