| Autor: |
Patel, Nisha D., Jannapureddy, Suneal R., Hwang, Willy, Chaudhry, Imran, Boriek, Aladia M. |
| Předmět: |
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| Zdroj: |
American Journal of Physiology: Cell Physiology; Apr2003, Vol. 284 Issue 4, pC962, 7p, 3 Diagrams, 5 Graphs |
| Abstrakt: |
Sarcoglycan (ASG) is a transmembrane protein of the dystrophinassociated complex, and absence of ASG causes limb-girdle muscular dystrophy. We hypothesize that disruption of the sarcoglycan complex may alter muscle extensibility and disrupt the coupling between passive transverse and axial contractile elements in the diaphragm. We determined the length-tension relationships of the diaphragm of young ASGdeficient mice and their controls during uniaxial and biaxial loading. We also determined the isometric contractile properties of the diaphragm muscles from mutant and normal mice in the absence and presence of passive transverse stress. We found that the diaphragm muscles of the null mutants for the protein ASG show 1) significant decrease in muscle extensibility in the directions of the muscle fibers and transverse to fibers, 2) significant reductions in force-generating capacity, and 3) significant reductions in coupling between longitudinal and transverse properties. Thus these findings suggest that the sarcoglycan complex serves a mechanical function in the diaphragm by contributing to muscle passive stiffness and to the modulation of the contractile properties of the muscle. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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