Evaluation of the serum cystatin C values in prediction of indications for hemodialysis in patients with chronic renal failure.

Autor: Sit, Dede, Basturk, Taner, Yildirim, Süleyman, Karagoz, Ferdi, Bozkurt, Nalan, Gunes, Ayşegül
Zdroj: International Urology & Nephrology; Jan2014, Vol. 46 Issue 1, p57-62, 6p
Abstrakt: Background: Indications of dialysis treatment for patients with end-stage renal disease depend on various clinical and laboratory parameters. In this study, we aimed to determine whether standardized serum cystatin C (SCC) equation may be an applicability of marker for dialysis initiation and its relationship to other clearance values among patients with advanced chronic kidney disease. Materials and methods: A total of 84 patients (45 males, 39 females) aged 19-89 were evaluated in this study. Hemodialysis was indicated according to clinical and laboratory findings, and estimated glomerular filtration rate (eGFR) was according to four different formulas [MDRD, EpiCKD, Cockcroft Gault formula (CGF) and SCC equation]. Results: eGFR values of patients in the study were 7.23 ± 3.26, 7.86 ± 3.78, 15.09 ± 10.88 and 11.31 ± 4.54 according to MDRD, EpiCKD, SCC equation and CGF, respectively. There was a positive correlation between MDRD, EpiCKD and CGF, and between EpiCKD and CGF ( p < 0.01). Also, statistically significant correlation was found between SCC equation and CGF ( p < 0.05). Conclusion: SCC equation was not seemed to be an appropriate marker for starting dialysis in patients with advanced CKD. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index