| Abstrakt: |
A new series of compounds N-(4-(2-(3-(1 H-benzo[ d]imidazol-2-yl)-5-(aryl)-4,5-dihydro-1 H-pyrazol-1-yl)-2-oxoethoxy)phenyl)acetamides ( 5a- u) were synthesized and structures of these compounds were elucidated by spectral (IR, H NMR, C NMR, and mass spectra) analysis. Antimicrobial activity was measured against Escherichia coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688), Staphylococcus aureus (MTCC 96), Streptococcus pyogenes (MTCC 442), Candida albicans (MTCC 227), Aspergillus niger (MTCC 282), and Aspergillus clavatus (MTCC 1323) by serial broth dilution method. Evaluation of antimicrobial activity revealed that compounds 5f, 5i, 5q, and 5t were the most active antibacterial, while compounds 5e, 5g, 5h, 5j, 5p, 5r, and 5u were the most potent antifungal agents as compared to standard drugs and thus could be promising new lead molecules. [ABSTRACT FROM AUTHOR] |
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