Multi-ion pore behaviour in the CFTR chloride channel.

Autor: Tabcharani, Joseph A., Rommens, Johanna M.
Předmět:
Zdroj: Nature; 11/4/1993, Vol. 366 Issue 6450, p79, 4p, 1 Diagram, 14 Graphs
Abstrakt: Presents evidence that wild-type cystic fibrosis transmembrane conductance regulator (CFTR) can contain more than one anion simultaneously. Anomalous mole fraction effect of the wild-type CFTR; Importance of two positively charged residues in the sixth predicted transmembrane segment; Mutation of an arginine to a histidine.
Databáze: Complementary Index