Antibodies to Influenza Virus A/ H1 N1 Hemagglutinin in Type 1 Diabetes Children Diagnosed Before, During and After the SWEDISH A( H1 N1)pdm09 Vaccination Campaign 2009-2010.

Autor: Svensson, M., Ramelius, A., Nilsson, A.‐L., Delli, A. J., Elding Larsson, H., Carlsson, A., Forsander, G., Ivarsson, S. A., Ludvigsson, J., Kockum, I., Marcus, C., Samuelsson, U., Örtqvist, E., Lernmark, Å.
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Zdroj: Scandinavian Journal of Immunology; Feb2014, Vol. 79 Issue 2, p137-148, 12p
Abstrakt: We determined A/ H1 N1-hemagglutinin (HA) antibodies in relation to HLA- DQ genotypes and islet autoantibodies at clinical diagnosis in 1141 incident 0.7-to 18-year-old type 1 diabetes patients diagnosed April 2009-December 2010. Antibodies to 35S-methionine-labelled A/ H1 N1 hemagglutinin were determined in a radiobinding assay in patients diagnosed before ( n = 325), during ( n = 355) and after ( n = 461) the October 2009-March 2010 Swedish A( H1 N1)pdm09 vaccination campaign, along with HLA- DQ genotypes and autoantibodies against GAD, insulin, IA-2 and ZnT8 transporter. Before vaccination, 0.6% patients had A/ H1 N1- HA antibodies compared with 40% during and 27% after vaccination ( P < 0.0001). In children <3 years of age, A/H1N1- HA antibodies were found only during vaccination. The frequency of A/H1N1- HA antibodies during vaccination decreased after vaccination among the 3 < 6 ( P = 0.006) and 13 < 18 ( P = 0.001), but not among the 6 < 13-year-olds. HLA- DQ2/8 positive children <3 years decreased from 54% (15/28) before and 68% (19/28) during, to 30% (9/30) after vaccination ( P = 0.014). Regardless of age, DQ2/2; 2/X ( n = 177) patients had lower frequency ( P = 0.020) and levels ( P = 0.042) of A/ H1 N1- HA antibodies compared with non- DQ2/2; 2/X ( n = 964) patients. GADA frequency was 50% before, 60% during and 51% after vaccination ( P = 0.009). ZnT8 QA frequency increased from 30% before to 34% during and 41% after vaccination ( P = 0.002). Our findings suggest that young (<3 years) along with DQ2/2; 2/ X patients were low responders to Pandemrix®. As the proportion of DQ2/8 patients <3 years of age decreased after vaccination and the frequencies of GADA and ZnT8 QA were enhanced, it cannot be excluded that the vaccine affected clinical onset of type 1 diabetes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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