| Autor: |
Cherpitel, Cheryl J., Ye, Yu, Bond, Jason, Stockwell, Timothy, Vallance, Kate, Martin, Gina, Brubacher, Jeffrey R., MacPherson, Andrew |
| Předmět: |
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| Zdroj: |
Alcoholism: Clinical & Experimental Research; Jan2014, Vol. 38 Issue 1, p235-240, 6p |
| Abstrakt: |
Background The magnitude of risk of injury from drinking, based on emergency department ( ED) studies, has been found to vary considerably across studies, and the impact of study design on this variation is unknown. Methods Patients were interviewed regarding drinking within 6 hours prior to the injury or illness event, drinking during the same time the previous week, and usual drinking during the last 30 days. Risk estimates were derived from case-control analysis and from both pair-matched and usual frequency case-crossover analysis. Results The odds ratio ( OR) based on case-control (2.7; 1.9 to 3.8) was larger than that based on pair-matched case-crossover analysis (1.6; 1.0 to 2.6). The control-crossover estimate suggested the case-crossover estimate was an underestimate of risk, and when this adjustment was applied to the case-crossover estimate, risk of injury increased ( OR = 3.2; 1.7 to 6.0). Adjusted case-crossover estimates compared with unadjusted showed the largest proportional increase at 7 or more drinks prior to injury ( OR = 7.1; 2.2 to 22.9). The case-crossover estimate based on usual frequency of drinking was substantially larger ( OR = 10.7; 8.0 to 14.3) than that based on case-control or pair-matched case-crossover analysis, but less than either when adjusted based on control-crossover usual frequency analysis ( OR = 2.2; 1.5 to 3.3). Conclusions The data suggest that while risk of injury based on case-control analysis may be biased, control data are important in providing adjustments derived from control-crossover analysis to case-crossover estimates, and are most important at higher levels of consumption prior to the event. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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