Exercise capacity, daily activity, and severity of fatigue in term born young adults after neonatal respiratory failure.

Autor:	Cammen‐van Zijp, M. H. M., Spoel, M., Laas, R., Hop, W. C. J., Jongste, J. C., Tibboel, D., Berg‐Emons, R. J. G., IJsselstijn, H.
Předmět:	RESPIRATORY insufficiency treatment ANALYSIS of variance CARDIOPULMONARY system STATISTICAL correlation CYCLING DIAPHRAGMATIC hernia EXERCISE EXERCISE tests FATIGUE (Physiology) GENETIC disorders HEALTH status indicators HEALTH surveys HEART beat LACTATES NEONATAL intensive care PROBABILITY theory PULMONARY gas exchange QUESTIONNAIRES RESEARCH funding RESPIRATORY measurements SPIROMETRY STATISTICS T-test (Statistics) THERAPEUTIC complications U-statistics DATA analysis ANAEROBIC threshold BODY mass index NEONATAL intensive care units ACCELEROMETRY OXYGEN consumption ERGOMETRY VITAL capacity (Respiration) CASE-control method PHYSICAL activity DATA analysis software EXERCISE tolerance DISEASE complications CHILDREN
Zdroj:	Scandinavian Journal of Medicine & Science in Sports; Feb2014, Vol. 24 Issue 1, p144-151, 8p, 1 Diagram, 6 Charts
Abstrakt:	Little is known about long-term effects of neonatal intensive care on exercise capacity, physical activity, and fatigue in term borns. We determined these outcomes in 57 young adults, treated for neonatal respiratory failure; 27 of them had congenital diaphragmatic hernia with lung hypoplasia (group 1) and 30 had normal lung development (group 2). Patients in group 2 were age-matched, with similar gestational age and birth weight, and similar neonatal intensive care treatment as patients in group 1. All patients were born before the era of extracorporeal membrane oxygenation, nitric oxide administration, and high frequency ventilation. Exercise capacity was measured by cycle ergometry, daily physical activity with an accelerometry-based activity monitor, and fatigue by the fatigue severity scale. Median (range) VO2peak in mL/kg/min was 35.4 (19.6-55.0) in group 1 and 37.6 (15.7-52.7) in group 2. There was a between-group P-value of 0.65 for exercise capacity. Daily activity and fatigue were also similar in both groups. So, residual lung hypoplasia did not play an important role in this cohort. There were no significant associations between exercise capacity and perinatal characteristics. Future studies need to elucidate whether exercise capacity is impaired in patients with more severe lung hypoplasia who nowadays survive. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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