| Autor: |
Kustanovich, V, Merriman, B, McGough, J, McCracken, J T, Smalley, S L, Nelson, S F |
| Předmět: |
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| Zdroj: |
Molecular Psychiatry; 2003, Vol. 8 Issue 3, p309, 7p |
| Abstrakt: |
Attention-deficit hyperactivity disorder (ADHD) is the most common childhood psychiatric disorder, affecting 5–10% of school-age children. Although the biological basis of this disorder is unknown, twin and family studies provide strong evidence that ADHD has a genetic basis involving multiple genes. A previous study found an association between ADHD and two polymorphisms in the 3' untranslated region (UTR) of SNAP-25, a gene encoding a synaptic vesicle docking protein known to play a role in the hyperactivity observed in the Coloboma mouse strain. In this paper, we test biased transmission of the 3' UTR SNAP-25 haplotype using a larger ADHD sample of 113 families with 207 affected children. Using the transmission disequilibrium test (TDT), we found a trend consistent with biased transmission of the TC haplotype of SNAP-25 in all transmissions and detected a significant distortion (P = 0.027) when paternal transmissions were evaluated. Molecular Psychiatry (2003) 8, 309–315. doi:10.1038/sj.mp.4001247. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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