| Autor: |
Gray, Robert E., Tanner, Charles J., Pories, Walter J., MacDonald, Kenneth G., Houmard, Joseph A. |
| Předmět: |
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| Zdroj: |
American Journal of Physiology: Endocrinology & Metabolism; Apr2003, Vol. 47 Issue 4, pE726, 7p, 1 Chart, 9 Graphs |
| Abstrakt: |
The purpose of this study was to test the hypothesis that weight loss results in a reduction in intramuscular lipid (IMCL) content that is concomitant with enhanced insulin action. Muscle biopsies were obtained from morbidly obese individuals [body mass index (BMI) 52.2 ± 2.5 kg/m²; n = 6] before and after gastric bypass surgery, an intervention that improves insulin action. With intervention, there was a 47% reduction (P < 0.01) in BMI and a 93% decrease in homeostasis model assessment, or HOMA (7.0 ± 1.9 vs. 0.5 ± 0.1). Histochemically determined IMCL content decreased (P < 0.05) by ∼30%. In relation to fiber type, IMCL was significantly higher in type I vs. type II fibers. In both fiber types, there were reductions in IMCL and trends for muscle atrophy. Despite these two negating factors, the IMCL-to-fiber area ratio still decreased by ∼44% with weight loss. In conclusion, despite differing initial levels and possible atrophy, weight loss appears to decrease IMCL deposition to a similar relative extent in type I and II muscle fibers. This reduction in intramuscular triglyceride may contribute to enhanced insulin action seen with weight loss. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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