Evolving hypopituitarism following cranial irradiation.

Autor:	Kanumakala, S, Warne, Gl, Zacharin, Mr, Warne, G L, Zacharin, M R
Předmět:	ASTROCYTOMAS TUMORS PITUITARY gland BRAIN tumor diagnosis BRAIN tumors COMBINATION drug therapy COMPARATIVE studies GLIOMAS HYPOTHYROIDISM LONGITUDINAL method RESEARCH methodology MEDICAL cooperation PRECOCIOUS puberty RADIATION doses RADIOTHERAPY RESEARCH RISK assessment TIME EVALUATION research SEVERITY of illness index HYPOPITUITARISM
Zdroj:	Journal of Paediatrics & Child Health; Apr2003, Vol. 39 Issue 3, p232-235, 4p
Abstrakt:	Increasing survival after treatment for childhood cancer in recent years has left many patients with long-term sequelae. Following cranial irradiation, changes in hypothalamic-pituitary function evolve over several years and multiple hormone deficiencies are frequently found. In the present study we describe a boy whose initial presentation with a cerebral tumour included central precocious puberty. He was followed for more than 15 years and sequentially developed deficiencies of growth hormone, thyroid-stimulating hormone, gonadotrophins and adrenocorticotropic hormone after high-dose cranial irradiation. Long-term endocrine follow up of such children is essential for the early diagnosis and optimal management of hormone deficiencies. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text