| Autor: |
Lademann, Juergen, Martschick, anja, Kluschke, Franziska, Richter, Heike, Fluhr, Joachim W., Patzelt, alexa, Jung, Sora, Chekerov, Radoslav, Darvin, Maxim E., Haas, Norbert, Sterry, Wolfram, Zastrow, Leonhard, Sehouli, Jalid |
| Předmět: |
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| Zdroj: |
Skin Pharmacology & Physiology; Jan2014, Vol. 27 Issue 2, p66-70, 5p |
| Abstrakt: |
Background: Pegylated liposomal doxorubicin (PLD) is a highly efficient chemotherapeutic; however, it induces dermal side effects such as palmar-plantar erythrodysesthesia (PPE) in up to 80% of cases, probably by being emitted with the sweat onto the skin surface. Aim: The aim of the present study was to examine whether a topically applied ointment containing antioxidants with a high radical protection factor is able to prevent the formation of PPE. Methods: Twenty patients suffering from ovarian carcinoma and treated with PLD were observed. Results: 60% of the patients tolerated the regular application of the cream and developed no PPE. The remaining 40% interrupted the application. Six of them developed PPE and resumed ointment application thereafter. In these cases the PPE disappeared or was strongly reduced. Conclusion: The results of the observation clearly demonstrate that topical application of the ointment is an efficient strategy against the development of PPE during chemotherapy with PLD. Copyright © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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