| Autor: |
Sillerud, Laurel O., Solberg, Nathan O., Chamberlain, Ryan, Orlando, Robert A., Heidrich, John E., Brown, David C., Brady, Christina I., Vander Jagt, Thomas A., Garwood, Michael, Vander Jagt, David L. |
| Předmět: |
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| Zdroj: |
Journal of Alzheimer's Disease; 2013, Vol. 34 Issue 2, p349-365, 17p |
| Abstrakt: |
In our program to develop non-invasive magnetic resonance imaging (MRI) methods for the diagnosis of Alzheimer's disease (AD), we have synthesized antibody-conjugated, superparamagnetic iron oxide nanoparticles (SPIONs) for use as an in vivo agent for MRI detection of amyloid-β plaques in AD. Here we report studies in AβPP/PS1 transgenic mice, which demonstrate the ability of novel anti-AβPP conjugated SPIONs to penetrate the blood-brain barrier to act as a contrast agent for MR imaging of plaques. The conspicuity of the plaques increased from an average Z-score of 5.1 ± 0.5 to 8.3 ± 0.2 when the plaque contrast to noise ratio was compared in control AD mice with AD mice treated with SPIONs. The number of MRI-visible plaques per brain increased from 347 ± 45 in the control AD mice, to 668 ± 86 in the SPION treated mice. These results indicated that our SPION enhanced amyloid-β detection method delivers an efficacious, non-invasive MRI detection method in transgenic mice. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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