| Autor: |
Chelioti, E., Gkalitsiou, E., Sotiraki, M., Efthymiou, E., Mikros, S., Papalexandrou, A., Tsilivigou, M., Papadakis, G. |
| Předmět: |
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| Zdroj: |
Scientific Chronicles / Epistimonika Chronika; Apr2013, Vol. 18 Issue 2, p107-110, 4p |
| Abstrakt: |
We report a case of membranoproliferative glomerulonephritis (MPGN) with IgM k deposits in a patient with chronic HCV infection and simultaneous onset of monoclonal IgM + k gammopathy with concurrent small B-cell lymphoproliferative disease. The patient was presented with hepatosplenomegaly and a uremic state that necessitated dialysis therapy without any clinical signs of systemic disease apart from the chronic HCV infection. The diagnostic approach led to a renal biopsy that revealed MPGN with dominant IgM k deposits and lymphoid cells infiltrating the intestistium. The immunofluoresence was positive for the CD 20 B-cell marker while CD 5 was absent. The bone marrow biopsy that followed was consistent with lymphoplasmacytic lymphoma of small B-cell with plasmacytic differentiation. The immunophenotype turned positive for CD 20 and negative for CD 5. These histologic findings suggested the diagnosis of splenic marginal zone lymphoma. The patient became hemodialysis dependent and due to the indolent course of splenic marginal zone lymphoma was regularly monitored for potential transform to a high grade lymphoma. Our case emphasize that the renal biopsy is a powerful diagnostic tool and can offer valuable information for diagnosis rare lymphoproliferative disorders in cases with predominant renal disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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