| Autor: |
Tsuchiya, Kaoru, Asahina, Yasuhiro, Matsuda, Shuya, Muraoka, Masaru, Nakata, Toru, Suzuki, Yuichiro, Tamaki, Nobuharu, Yasui, Yutaka, Suzuki, Shoko, Hosokawa, Takanori, Nishimura, Takashi, Ueda, Ken, Kuzuya, Teiji, Nakanishi, Hiroyuki, Itakura, Jun, Takahashi, Yuka, Kurosaki, Masayuki, Enomoto, Nobuyuki, Izumi, Namiki |
| Předmět: |
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| Zdroj: |
Cancer (0008543X); Jan2014, Vol. 120 Issue 2, p229-237, 9p |
| Abstrakt: |
BACKGROUND A new predictive biomarker for determining prognosis in patients with hepatocellular carcinoma (HCC) who receive sorafenib is required, because achieving a reduction in tumor size with sorafenib is rare, even in patients who have a favorable prognosis. Vascular endothelial growth factor (VEGF) receptor is a sorafenib target. In the current study, the authors examined changes in plasma VEGF concentrations during sorafenib treatment and determined the clinical significance of VEGF as a prognostic indicator in patients with HCC. METHODS Plasma VEGF concentrations were serially measured in 63 patients with advanced HCC before and during sorafenib treatment. A plasma VEGF concentration that decreased >5% from the pretreatment level at 8 weeks was defined as a 'VEGF decrease.' An objective tumor response was determined using modified Response Evaluation Criteria in Solid Tumors 1 month after the initiation of therapy and every 3 months thereafter. RESULTS Patients who had a VEGF decrease at week 8 (n = 14) had a longer median survival than those who did not have a VEGF decrease (n = 49; 30.9 months vs 14.4 months; P = .038). All patients who had a VEGF decrease survived for >6 months, and the patients who had both a VEGF decrease and an α-fetoprotein response (n = 6) survived during the observation period (median, 19.7 months; range, 6.5-31.0 months). In univariate analyses, a VEGF decrease, radiologic findings classified as progressive disease, and major vascular invasion were associated significantly with 1-year survival; and, in multivariate analysis, a VEGF decrease was identified as an independent factor associated significantly with survival. CONCLUSIONS A plasma VEGF concentration decrease at 8 weeks after starting sorafenib treatment may predict favorable overall survival in patients with advanced HCC. Cancer 2014;120:229-237. © 2013 American Cancer Society. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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