| Autor: |
Kholod, O., Bakhmachuk, A., Shvachko, L. |
| Předmět: |
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| Zdroj: |
Bulletin of Taras Shevchenko National University of Kyiv / Vestnik Kievskogo Nacionalnogo Universiteta Imeni Tarasa Sevcenko; 2013, Vol. 64 Issue 2, p7-10, 4p |
| Abstrakt: |
EMT - the epithelial-to-mesenchimal transduction is the basis platform of the tumor microenvironment. EMT causatively binding with the tumor progression, by which are modulated the migrational, invasive and metastatic potentials of the tumor cells. Therefore, EMT is the crucial microenvironment metastatic niche for the final cancer cell aggressiveness. Moreover, EMT underlie cancer stem cell induction and also controls tumor drug sensitivity modulating the response of cancer cells to chemotherapy. The earlier event of EMT metastatic cascade is the epigenetic deregulation of the E-cadherin-beta-catenin adhesive signaling. The promoter DNA hypermethylation of E-cadherine gene as the key adhesive molecules results in the switch the E-cadherin-betacatenin adhesive signaling on the canonic beta-catenin-Wnt signaling associated with epithelial-mesenchimal transduction. Thus, the epigenetic regulation of EMT might be considered as the target for a new cancer epigenetic therapy strategies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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