| Autor: |
Alcântara Camejo, Flavio, Almeida, Luis Eduardo, Doetzer, Andrea Duarte, Caporal, Karina São Thiago, Ambros, Viviane, Azevedo, Marina, Alanis, Luciana Reis Azevedo, Olandoski, Marcia, Noronha, Lucia, Trevilatto, Paula Cristina |
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| Zdroj: |
Journal of Oral Pathology & Medicine; Jan2014, Vol. 43 Issue 1, p69-75, 7p, 3 Color Photographs, 4 Charts |
| Abstrakt: |
Background Apoptosis is a programme of cell death which does not induce an inflammatory response. Recent previous research has suggested a correlation between temporomandibular internal derangement and apoptosis. Fas ligand (Fas L) is an apoptosis-inducing factor, known to trigger apoptosis through distinct signal pathways. This study aims to examine, by immunohistochemistry, the expression of Fas L in temporomandibular joint ( TMJ) articular discs of patients with anterior disc displacement with reduction ( ADDwR) and without reduction ( ADDwoR) in patients with and without osteoarthrosis ( OA). Methods Forty-two ( n = 42) TMJ articular discs were divided into two cut-offs: (i) 8 control, 17 ADDwR, 17 ADDwoR, and (ii) without OA ( n = 25) and with OA ( n = 17). The area of immunostaining was compared statistically between groups ( P < 0.05). Results Statistically significant differences were found in the expression of Fas L in TMJ discs between the three groups ( P = 0.001). ADDw R presented significant higher Fas L expression when compared with ADDwo R ( P < 0.001). Significant higher Fas L expression was observed in the group without OA ( P = 0.001). All patients without OA presented ADDw R, while all the patients with OA presented ADDwo R. Conclusion A higher area of in situ immunostaining of Fas L was found in temporomandibular discs with reduction, which is the less severe condition. Moreover, a reduced expression of Fas L in the discs of patients with osteoarthrosis was found, suggesting that some aspects of apoptosis might underlie the progression of TMJ disorders. [ABSTRACT FROM AUTHOR] |
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Complementary Index |
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