Mitogen-activated protein kinases enhance long-range activation by the...-globin locus control...

Autor: Versaw, Wayne K., Blank, Volker, Andrews, Nancy M.
Předmět:
Zdroj: Proceedings of the National Academy of Sciences of the United States of America; 07/21/98, Vol. 95 Issue 15, p8756, 5p, 3 Black and White Photographs, 1 Chart, 9 Graphs
Abstrakt: Reports on a study which indicated that the mitogen-activated protein kinase pathway's activation by low concentrations of the phorbol ester phorbol 12-tetradecanoate 13-acetate, induced the locus control region (LCR) subregion HS2 enhancer activity, using stable transfection assays. Indication that HS3 was not activated; Composition of LCR; Cotransfection of K562 cells by electroporation; Methodology used to conduct the study; Results of the study.
Databáze: Complementary Index