Treatment of Relapsing Refractory Diffuse Large Cell Lymphoma After Matched Unrelated Donor Bone Marrow Transplant with Immunosuppression Withdrawal and Rituximab.

Autor: Wong, Raymond, De Lima, Marcos, Couriel, Daniel, Giralt, Sergio, Hosing, Chitra, Shahjahan, Munir, Yee Chung Cheng, Bruton, Jill, Champlin, Richard, Khouri, Issa
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Zdroj: Leukemia & Lymphoma; May2003, Vol. 44 Issue 5, p829, 4p
Abstrakt: A 31-year-old man with a diffuse large-cell lymphoma in first refractory relapse received a bone marrow transplant (BMT) from a matched unrelated donor using CAMPATH-1H, carmustine, etoposide, cytarabine and melphalan as conditioning regimen, and methotrexate and tacrolimus for graft-versus-host disease (GVHD) prophylaxis. The transplant was complicated by grade II skin acute GVHD. Lymphoma relapse occurred 4 months post-transplant. Immunosuppression withdrawal plus rituximab induced a complete response. He remains in complete remission (CR) 11 months postimmunosuppression withdrawal and 15 months post-transplant. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index