Synthesis of New 1,2,4-Triazole-5-Thiones and Their Thioglycoside Derivatives as Potential Antibacterial Agents.

Autor: Dilmaghani, Karim Akbari, Pur, Fazel Nasuhi, Jazani, Nima Hoseini, Alavi, Asma, Niknam, Zahra, Mirfakhraee, Farrin
Předmět:
Zdroj: Phosphorus, Sulfur & Silicon & the Related Elements; Jan2014, Vol. 189 Issue 1, p81-87, 7p
Abstrakt: Abstract The glycosylation of 1,2,4-triazole-5-thiones has been performed with peracetylated β-pyranosyl bromide in the presence of potassium carbonate. The synthesized compounds were tested for their antimicrobial activity against bacterial (Gram-negative and Gram-positive) and yeasts strains in vitro. The synthetic compounds showed different inhibition zones against tested bacterial and yeasts strains. Among them, compounds which possessed 2-furyl and p-bromophenyl moieties showed the best results against Acinetobacter calcoaceticus ATCC 23055. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index