| Autor: |
Rocha, Conceição, Mendonça, Teresa, Eduarda Silva, Maria |
| Předmět: |
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| Zdroj: |
Mathematical & Computer Modelling of Dynamical Systems; Dec2013, Vol. 19 Issue 6, p540-556, 17p |
| Abstrakt: |
During surgical interventions, a muscle relaxant drug is frequently administered with the objective of inducing muscle paralysis. Clinical environment and patient safety issues lead to a huge variety of situations that must be taken into account requiring intensive simulation studies. Hence, population models are crucial for research and development in this field. This work develops a stochastic population model for the neuromuscular blockade (NMB) (muscle paralysis) level induced byatracuriumbased on a deterministic individual model already proposed in the literature. To achieve this goal, a jointLognormaldistribution is considered for the patient-dependent parameters. This study is based on clinical data collected during general anaesthesia. The procedure developed enables to construct a reliable reference bank of parametrized models that not only reproduces the overall features of the NMB, but also the inter-individual variability characteristic of physiological signals. It turns out that this bank constitutes a fundamental tool to support research on identification and control algorithms and is suitable to be integrated in clinical decision support systems. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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