Safety and efficacy of a new parenteral lipid emulsion ( SMOF) for surgical patients: a systematic review and meta-analysis of randomized controlled trials.

Autor:	Tian, Hongliang, Yao, Xiangrong, Zeng, Rong, Sun, Rao, Tian, Hongyan, Shi, Chunhu, Li, Lun, Tian, Jinhui, Yang, Kehu
Předmět:	PARENTERAL feeding RESEARCH methodology evaluation INTRAVENOUS fat emulsions ENZYME metabolism ALKALINE phosphatase ASPARTATE aminotransferase C-reactive protein CHI-squared test CONFIDENCE intervals CLINICAL drug trials EPIDEMIOLOGY EXPERIMENTAL design FISH oils LENGTH of stay in hospitals MEDICAL databases INFORMATION storage & retrieval systems MEDICAL information storage & retrieval systems LIVER LOW density lipoproteins MEDLINE META-analysis OLIVE oil ONLINE information services PARENTERAL solutions PATIENTS POSTOPERATIVE care SOY oil SURGERY TRIGLYCERIDES SYSTEMATIC reviews EVIDENCE-based medicine PROFESSIONAL practice DATA analysis ALANINE aminotransferase PUBLICATION bias DATA analysis software ADVERSE health care events DESCRIPTIVE statistics EVALUATION THERAPEUTICS
Zdroj:	Nutrition Reviews; Dec2013, Vol. 71 Issue 12, p815-821, 7p, 2 Diagrams, 3 Charts
Abstrakt:	To assess the comparative safety and efficacy of a new parenteral lipid emulsion containing soybean oil, medium-chain triglycerides, olive oil, and fish oil ( SMOFlipid20%) for postoperative patients, a meta-analysis of randomized controlled trials ( RCTs) was conducted. Six RCTs with a total of 306 patients were included in the analysis. The overall quality of evidence for each outcome was evaluated using Grading of Recommendations, Assessment, Development, and Evaluation ( GRADE) software. Compared with a soybean-based ( Lipoven20%) and a soybean- and olive oil-based ( Clin Oleic20%) lipid emulsion, SMOFlipid20% was associated with lower levels of hepatic enzymes, suggesting less toxicity. Changes in low-density lipoprotein triglyceride and C-reactive protein levels were also lower with SMOFlipid20% compared with Lipoven20%. Differences between SMOFlipid20% and a lipid emulsion containing medium- and long-chain triglycerides ( MCT/ LCT20%) were not statistically significant. For all trials, there were no significant differences in adverse events and length of hospital stay. The quality of evidence from the RCTs evaluating SMOF20% versus Lipoven20% was moderate, while most of the evidence from RCTs of SMOF20% versus Clin Oleic20% and MCT/ LCT20% lipid emulsions was low. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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