An individualised treatment algorithm for tumour stage 1 glottic squamous cell carcinoma.
| Autor: | Aydil, U, Akmansu, M, Kizil, Y, Yazici, Ö, Üstün, S, Karaloğlu, F, Köybaşioğlu, A |
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| Předmět: |
ACADEMIC medical centers
CANCER relapse CHI-squared test FISHER exact test GLOTTIS LARYNGEAL tumors MEDICAL lasers HEALTH outcome assessment SQUAMOUS cell carcinoma T-test (Statistics) TREATMENT effectiveness RETROSPECTIVE studies DATA analysis software INDIVIDUALIZED medicine DESCRIPTIVE statistics KAPLAN-Meier estimator |
| Zdroj: | Journal of Laryngology & Otology; Nov2013, Vol. 127 Issue 11, p1127-1133, 7p |
| Abstrakt: | Objective:To report and discuss the outcome of a treatment algorithm for patients with tumour stage 1 glottic squamous cell carcinoma.Method:A retrospective outcome analysis study was performed using data from a tertiary referral centre.Results:Sixty-nine patients were treated with radiotherapy and 26 with surgery, in accordance with the treatment algorithm. Five-year overall survival rates were the same for both treatment groups (92 per cent). Five-year disease-specific survival rates were 100 per cent for surgery, 98 per cent for radiotherapy and 99 per cent overall. The overall 5-year laryngeal preservation rate was 89.1 per cent, being 95.7 per cent for surgery patients and 86.7 per cent for radiotherapy patients (p = 0.502). There was no significant association between laryngeal preservation rates and age (p = 0.779), anterior commissure involvement (p = 0.081), tumour stage (1a or 1b) (p = 0.266) or treatment modality (surgery or radiotherapy; p = 0.220). There was no significant difference in local recurrence rates between the two treatment groups (19.3 per cent for radiotherapy vs 10.0 per cent for surgery; p = 0.220). The overall 5-year regional recurrence rate was 1.2 per cent.Conclusion:Tumour stage 1 glottic carcinoma can be managed with different treatment modalities, following an individualised treatment algorithm, with results comparable to published outcomes. [ABSTRACT FROM PUBLISHER] |
| Databáze: | Complementary Index |
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