No association between the intake of marine n-3 PUFA during the second trimester of pregnancy and factors associated with cardiometabolic risk in the 20-year-old offspring.
| Autor: | Rytter, Dorte, Bech, Bodil H., Halldorsson, Thorhallur, Christensen, Jeppe H., Schmidt, Erik B., Danielsen, Inge, Henriksen, Tine B., Olsen, Sjurdur F. |
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| Předmět: |
ADIPOSE tissues
BLOOD pressure HUMAN body composition C-reactive protein CARDIOVASCULAR diseases CHI-squared test CHOLESTEROL CONFIDENCE intervals GLYCOSYLATED hemoglobin HEART beat HIGH density lipoproteins INSULIN resistance INTERVIEWING LONGITUDINAL method LOW density lipoproteins RESEARCH methodology OMEGA-3 fatty acids QUESTIONNAIRES RESEARCH funding SEAFOOD STATISTICAL hypothesis testing T-test (Statistics) TRIGLYCERIDES LEPTIN MULTIPLE regression analysis DATA analysis software ADIPONECTIN WAIST circumference PRENATAL exposure delayed effects ADULTS PREGNANCY |
| Zdroj: | British Journal of Nutrition; 12/14/2013, Vol. 110 Issue 11, p2037-2046, 10p |
| Abstrakt: | The intake of marine n-3 PUFA has been shown to decrease the risk of CVD in a number of studies. Since the development of CVD is often a lifelong process, marine n-3 PUFA intake early in life may also affect the development of later CVD. The aim of the present study was to investigate the association between maternal intake of marine n-3 PUFA during the second trimester of pregnancy and factors associated with cardiometabolic risk in the 20-year-old offspring. The study was based on the follow-up of the offspring of a Danish pregnancy cohort who participated in a study conducted from 1988 to 1989. A total of 965 pregnant women were originally included in the cohort and detailed information about the intake of marine n-3 PUFA during the second trimester was collected. In 2008–9, the offspring were invited to participate in a clinical examination including anthropometric, blood pressure (BP) and short-term heart rate variability measurements. Also, a fasting venous blood sample was drawn from them. Multiple linear regression modelling, using the lowest quintile of marine n-3 PUFA intake as the reference, was used to estimate the association with all outcomes. A total of 443 offspring participated in the clinical examination. No association between the intake of marine n-3 PUFA during the second trimester of pregnancy and offspring adiposity, glucose metabolism, BP or lipid profile was found. In conclusion, no association between the intake of marine n-3 PUFA during the second trimester of pregnancy and the factors associated with cardiometabolic risk in the 20-year-old offspring could be detected. [ABSTRACT FROM PUBLISHER] |
| Databáze: | Complementary Index |
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