| Autor: |
Karim, Shermin, Pratibha, P. K., Kamath, Shobha, Bhat, G. Subraya, Kamath, Ullas, Dutta, Babi, Sharma, Naveen, Archana, B., Bhat, K. Mahalinga, Guddattu, Vasudev |
| Předmět: |
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| Zdroj: |
Dental Research Journal; May2012, Vol. 9 Issue 3, p266-272, 7p, 5 Charts |
| Abstrakt: |
Background: The possibility of impaired antioxidant status and so increased oxidative damage in periodontal disease is being conjectured. The present randomized controlled study was carried out with the objective of analyzing the activity of superoxide dismutase enzyme and thiol antioxidants in gingival crevicular fluid (GCF) and saliva as indicators of response to periodontal therapy. Materials and Methods: Subjects were screened and randomly divided into three groups: 23 periodontally healthy controls, 24 with gingivitis, and 23 with periodontitis. Based on the clinical attachment levels, the periodontitis group was further divided into subgroups, including mild, moderate, and severe periodontitis. GCF and saliva samples were collected for estimation of superoxide dismutase and thiol antioxidant concentrations at baseline and 15 days after nonsurgical treatment. Intragroup comparisons were statistically analyzed using repeated measures analysis of covariance (P value <0.05). Results: Superoxide dismutase was present in greater quantities in the GCF compartment (100.32±3.67 U/0.5 mL) than in saliva (39.99±3.52 U/0.5 mL), with elevated levels in mild and moderate subgroups as compared with severe periodontitis. Thiol concentrations were comparable in these media, 14.43±1.57 micromol /L in GCF and 15.09±2.26 micromol/L in saliva. Following treatment, superoxide dismutase and thiol antioxidant concentrations significantly improved in all the patient groups. Conclusion: The reduction of the inflammatory response following therapy resulted in improved antioxidant profiles in both the GCF and salivary compartments. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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