| Autor: |
Eskandari‐Nasab, Ebrahim, Moghadampour, Mehdi, Hasani, Seyed‐Shahaboddin, Hadadi‐fishani, Mehdi, Mirghanizadeh‐Bafghi, Seyyed‐Ali, Asadi‐Saghandi, Abolghasem, Zare, Fateme, Sadeghi‐Kalani, Behrooz, Ghazali‐bina, Mehran |
| Předmět: |
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| Zdroj: |
Microbiology & Immunology; Nov2013, Vol. 57 Issue 11, p785-791, 7p |
| Abstrakt: |
ABSTRACT Interferon-gamma (IFN-γ) is a pro-inflammatory cytokine that plays a pivotal role in the defense mechanism against Brucella infection. It was hypothesized that the IFN-γ in (+874 A/T in intron 1) TT and +5644 T/A, TT genotypes, which are reportedly associated with high IFN production, are associated with susceptibility to brucellosis in Iranian subjects. Genotyping of these IFN-γ variants by an allele-specific polymerase chain reaction method was performed in 281 subjects, comprising 153 patients with active brucellosis and 128 healthy controls. It was found that the +874 minor allele (A) and homozygote genotype (AA) were significantly more frequently present in brucellosis patients than in controls (OR = 2.588; 95% CI, 1.313-5.104; P = 0.006 for the AA genotype; OR = 1.575; 95% CI, 1.124-2.216; P = 0.010 for the A allele). However, the allelic and genotypic distribution of the IFN-γ polymorphism at position UTR5644 A>T did not differ significantly between patients and controls ( P > 0.05). The distribution of haplotypes in this study suggests that the T/A haplotype (+874/UTR5644), which was present more frequently in controls than in patients, may protect subjects against Brucella infection. It is suggested that IFN-γ +874 AA genotype and A allele are risk factors for developing brucellosis infection in Iranian subjects. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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