The role of core biopsy in the preoperative classification of breast cancer according to prognostic factors.

Autor: Lanitis, S., Lazari, P., Kontovounisios, Ch., Karaliotas, Ch., Sgourakis, G., Tsikos, C., Barbati, K., Karaliotas, C.
Zdroj: Hellenic Journal of Surgery; Jan2013, Vol. 85 Issue 1, p1-7, 7p
Abstrakt: Aim-Background: This prospective study aimed to assess the reliability and accuracy of core biopsy (CB) in classifying tumours preoperatively according to prognostic factors. Methods: Fifty breast cancer patients with a mean age of 57.8 years underwent CB before the final operation. We compared the pathology results obtained from the CB specimen with those obtained from the final histology. Results: There was perfect agreement between the histological type on core biopsy and the final histology (K=1). There was also substantial agreement between the estimated and actual grade (K=0.766). There was almost perfect agreement for the oestrogen (k=0.932) and progesterone receptor status (k=0.802) between the 2 methods while there was perfect agreement for the Her2 positivity (K=1). There was substantial agreement for the Ki67 (R=0.621) and almost perfect agreement for the p53 results (R=0.858). Finally, when we classified the tumours into the 4 most common molecular subtypes (based on IHC), agreement was almost perfect (k=0.924). Conclusion: CB can be a reliable, safe and cost effective means of classifying tumours based on prognostic factors. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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