Anti-Chlamydia pneumoniae heat shock protein 10 antibodies in asthmatic adults

Autor: Betsou, Fotini, Sueur, Jean Marie, Orfila, Jeanne
Předmět:
Zdroj: FEMS Immunology & Medical Microbiology; Mar2003, Vol. 35 Issue 2, p107, 5p
Abstrakt: A multicenter prospective study was performed on 160 asthmatic adults suffering from acute episodes of bronchitis and 88 non-asthmatic controls, to investigate potential associations among Chlamydia pneumoniae infection and/or anti-C. pneumoniae heat shock protein 10 antibodies, and asthma. We used micro-immunofluorescence to detect serum anti-C. pneumoniae IgG, IgA and IgM antibodies and enzyme-linked immunosorbent assay to detect serum anti-Chsp10 peptide IgG antibodies. The serological prevalence of C. pneumoniae was 73.1%. An association was observed between the presence of anti-Chsp10 antibodies and adult onset asthma. The humoral immune responses were not confined to any particular region of the Chsp10 protein. [Copyright &y& Elsevier]
Databáze: Complementary Index