| Autor: |
Krishmaiah, Y. Venkata, Kishore, K., Sripathi, Babu, Vijayudu, B., Yugandhar, M., Kumari, K. Vijaya |
| Předmět: |
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| Zdroj: |
International Journal of Pharmacology & Biological Sciences; Aug2013, Vol. 7 Issue 2, p27-31, 5p |
| Abstrakt: |
Cisplatin is one of the drugs of choice to treat cancers. Use of this agent has been shown to impair the normal functioning of animals. The in vivo effect of Cisplatin and á-tocopherol on rat tissues total ATPase and cytochrome - C - oxidase activities was reported. Cisplatin at an administered dose of 1.5 mg/kg depleted both the above cited enzymatic activity levels and the 400 mg/kg átocopherol + 1.5 mg/kg Cisplatin over 24hours showed normalised trends of both the enzymes altered by Cisplatin. It is reported that á-tocopherol by way of its antioxidant mechanisms may normalise the Cisplatin altered rat tissue total ATPase and cytochrome - C - oxidase activity levels. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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