| Autor: |
Amadou, Claire, Kumanovics, Attila, Jones, Elsy P., Lambracht-Washington, Doris, Yoshino, Masayasu, Lindahl, Kirsten Fischer |
| Předmět: |
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| Zdroj: |
Immunological Reviews; Feb99, Vol. 167 Issue 1, p211-221, 11p |
| Abstrakt: |
We have assembled a contig of 81 yeast artificial chromosome clones that spans 8 Mb and contains the entire major histocompatibility complex (Mhc) from mouse strain C57BL/6 (H2[supb), and we are in the process of assembling an Mhc contig of bacterial artificial chromosome (BAC) clones from strain 129 (H2[supbc], which differs from C57BL/6 in the H2-Q and H2-T regions. The current BAC contig extends from Tapasin to D17Leh89 with gaps in the class II. H2-Q, and distal H2-H regions. Only four BAC clones were required to link the class I genes of the H2-Q and H2-T regions, and no new class I gene was found in the previous gap. The proximal 1 Mb of the H2-M region has been analyzed in detail and is ready for sequencing; it includes 21 class I genes or fragments, at least 14 olfactory receptor-like genes, and a number of non-class I genes that clearly establish a conserved synteny with the class I regions of the human and rat Mhc. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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