| Autor: |
Waldburger, Jean-Marc, Masternak, Krzysztof, Muhlethaler-Mottet, Annick, Villard, Jean, Peretti, Marie, Landmann, Salome, Reith, Walter |
| Předmět: |
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| Zdroj: |
Immunological Reviews; Dec2000, Vol. 178 Issue 1, p148, 18p |
| Abstrakt: |
Summary: Major histocompatibility complex class II (MHCII) molecules drive the development, activation and homeostasis of CD4[sup +] T-helper cells. They play a central role in key processes of the adaptive immune system, such as the generation of T-cell mediated immune responses, the regulation of antibody production and the development and maintenance of tolerance. It is thus not surprising that the absence of MHCII expression results in a severe primary immunodeficiency disease (the base lymphocyte syndrome (BLS). The genetic defects responsible for BLS do not lie within the MHCII locus, but in genes encoding transcription factors required for MHCII expression. A great deal of our current knowledge about the mechanisms regulating expression of MHCII genes has been derived from the study of BLS. Four different MHCII regulatory genes have been identified. These genes encode RFXANK, RFXS, RFXAP and CIITA. The first three are subunits of RFX, a ubiquitously expressed factor that binds to the promoters of all MHCII genes. RFX binds co-operatively with other factors to form a highly stable multiprotein complex referred to as the MHCII enhancesome. This enhancesome serves as a landing pad for the co-activator CIITA, which is recruited via protein--protein interactions. CIITA is the master control factor for MHCII expression. The highly regulated expression pattern of CIITA ultimately dictates the cell type specificity, induction and level of MHCII expression. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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