| Autor: |
Cho, Han-Gil, Choi, Jang-Hoon, Lee, Hyun-Kyung, Mun, Su-Kyoung, Lee, Jong-Bok, Jho, Eek-Hoon, Kang, Chun, Lim, Young-Hee |
| Předmět: |
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| Zdroj: |
Archives of Virology; Nov2013, Vol. 158 Issue 11, p2365-2370, 6p |
| Abstrakt: |
South Korean isolates of oseltamivir-resistant influenza viruses from 2005-2010 were investigated with a total 491 influenza viruses identified from 1702 specimens. Neuraminidase genes from 342 influenza viruses (71 A/H1N1, 74 pandemic A/H1N1 2009, 117 A/H3N2, and 80 B) were analyzed by RT-PCR with molecular markers for oseltamivir resistance. The H274Y mutation in the NA protein was identified in 100 % (n=40) of A/H1N1 viruses circulating in 2008-2009. Influenza A/H1N1 viruses harboring the H274Y substitution exhibited, on average, a 626-fold reduction in oseltamivir susceptibility and clustered with the A/Norway/1736/2007 strain. Close and timely monitoring for resistance to clinically available influenza antivirals should be consistently performed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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