| Autor: |
Mansuri, M. M., Seth, A. K., Molvi, K. I., Prajapati, B. R., Desai, D. G. |
| Předmět: |
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| Zdroj: |
Pharma Science Monitor; Apr2012, Vol. 3 Issue 2, p142-152, 11p |
| Abstrakt: |
Taking in to consideration of diverse biological activities of coumarin and thiazole derivatives, attempts have been made to attach a thiazole side chain at C-3 position of coumarin. In addition, to expand the structural diversity of synthetic courmarins for biological functions, the morpholine fusion at 2nd position of thiazole was also attempted. The compounds MM3M1 was synthesized keeping coumarin-3-yl constant at fifth position, morpholine at 2nd position and phenyl moiety at 4th position of thiazole nucleus. The compounds MM3M2, MM3M3 and MM3M4 were synthesized keeping coumarin-3- yl constant at fifth position, morpholine at 2nd position and introducing electron withdrawing group (-Cl) at ortho, meta and para position respectively in phenyl moiety at 4th position of thiazole nucleus. All the synthesized compounds were evaluated for their invitro antibacterial and anti-platelet activity. On the basis of structure-activity relationship studies of synthesized MM3M1- MM3M4 it can be concluded that presence of 2-chlorophenyl group at the 4th position of the thiazole contributes significantly to antibacterial and anti-platelet activity profile of the candidates. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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