| Autor: |
Prajapati, B. R., Seth, A. K., Molvi, K. I., Mansuri, M. M., Desai, D. G. |
| Předmět: |
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| Zdroj: |
Pharma Science Monitor; Apr2012, Vol. 3 Issue 2, p125-132, 8p |
| Abstrakt: |
The nitroheterocyclic compounds have proved to be very effective antimicrobial agents and very valuable member of limited armamentarium of antiprotozoal agents. A number of 5-nitoimidazole with substitution at 2-position with various substitutent are found to modify the antibacterial spectrum. Some 2-substituted nitroimidazole analogues were designed, synthesized and characterized. The synthesized compounds were tested for their antibacterial sensitivity against Gram-positive anaerobe (C. sporogenus) and Gramnegative anaerobe (B.fragilis) using macro broth dilution method. All the synthesized compounds exhibit good activity at 10 mcg/ml against Gram-negative anaerobe compared to standard control tinidazole and metronidazole, while remain inactive against Gram-positive anaerobe. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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