| Autor: |
Horne, David J., Narita, Masahiro, Spitters, Christopher L., Parimi, Soumya, Dodson, Sherry, Limaye, Ajit P. |
| Předmět: |
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| Zdroj: |
Clinical Infectious Diseases; Nov2013, Vol. 57 Issue 10, p1473-1482, 10p |
| Abstrakt: |
Despite published guidelines on latent and active tuberculosis in solid organ transplant (SOT) recipients, there remain areas of limited guidance. We discuss challenges in the diagnosis and management of tuberculosis and latent tuberculosis in SOT recipients and identify areas for further research.Solid organ transplant (SOT) recipients are at risk for opportunistic infections including tuberculosis. Although guidelines on the management of latent tuberculosis and active tuberculosis are available, there remain a number of clinical areas with limited guidance. We discuss challenges in the diagnosis, management, and treatment of latent and active tuberculosis in SOT candidates and recipients who reside in low-tuberculosis-prevalence areas. We discuss the diagnosis of latent tuberculosis in SOT candidates/recipients using tuberculin skin tests and interferon-γ release assays and risk stratification of SOT candidates/recipients that would identify individuals at high risk for latent tuberculosis despite negative test results. Through a careful review of posttransplant tuberculosis cases, we identify a history of treated tuberculosis in SOT recipients as a risk factor for development of posttransplant active tuberculosis. Finally, we include comparisons of recommendations by several large transplant organizations and identify areas for future research. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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