Prevalence of Ig E against neuromuscular blocking agents in hairdressers and bakers.

Autor: Dong, S., Acouetey, D. S., Guéant‐Rodriguez, R.‐M., Zmirou‐Navier, D., Rémen, T., Blanca, M., Mertes, P. M., Guéant, J.‐L.
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Zdroj: Clinical & Experimental Allergy; Nov2013, Vol. 43 Issue 11, p1256-1262, 7p
Abstrakt: Background Allergic IgE-mediated reactions to neuromuscular blocking agents ( NMBAs) are the main cause of immediate hypersensitivity reactions in anaesthesia; their predominant occurrence in the absence of previous exposure to NMBAs suggests a risk related to environmental exposure. Objective To investigate the prevalence of specific IgE to quaternary ammonium ions in two populations professionally exposed to quaternary ammonium compounds, in the north-eastern France. Methods The study had a retrospective follow-up design whereby apprentices were assessed after their 2-year training period as apprentices. The professionally exposed hairdresser populations ( n = 128) were compared with baker/pastry makers ( n = 108) and 'non-exposed' matched control subjects ( n = 379). Results We observed a 4.6-fold higher frequency of positive IgE against quaternary ammonium ions in hairdressers (HD), compared with baker/pastry makers (BP) and control (C) groups. The competitive inhibition of quaternary ammonium Sepharose radioimmunoassay (QAS-IgE RIA) with succinylcholine was significantly higher in HD, compared with BP and C groups, with inhibition percentage of 66.2 ± 7.4, 39.7 ± 6.0 and 43.8 ± 9.9, respectively ( P < 0.001). The specific IgE against quaternary ammonium ions recognized also two compounds widely used by hairdressers, benzalkonium chloride and polyquaternium-10, in competitive inhibition of IgE RIA. When considering the whole study population, hairdresser professional exposure and total IgE > 100 kU/L were the two significant predictors of IgE-sensitization against quaternary ammonium ions in the multivariate analysis of a model that included age, sex, professional exposure, increased concentration of total IgE (IgE > 100 kU/L) and positive IgE against prevalent allergens (Phadiatop®; P = 0.019 and P = 0.001, respectively). Conclusion and Clinical Relevance The exposure to hairdressing professional occupational factors increases Ig E-sensitization to NMBAs and quaternary ammonium ion compounds used in hairdressing. Besides the pholcodine hypothesis, our study suggests that repetitive exposure to quaternary ammonium compounds used in hairdressing is a risk factor for NMBAs sensitization. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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