Synthesis, structures, and properties of 15-oxoisosteviol thiosemicarbazone and oxime.

Autor:	Sharipova, R. R., Lodochnikova, O. A., Strobykina, I. Yu., Musin, R. Z., Babaev, V. M., Morozov, V. I., Pod“yachev, S. N., Chestnova, R. V., Kataev, V. E.
Předmět:	ORGANIC synthesis MOLECULAR structure STEVIOL THIOSEMICARBAZONES OXIMES DITERPENES X-ray diffraction ANTITUBERCULAR agents NITROGEN
Zdroj:	Russian Chemical Bulletin; Jan2013, Vol. 62 Issue 1, p175-182, 8p
Abstrakt:	New nitrogen-containing derivatives of the diterpenoid isosteviol (16-oxo- ent-beyeran-19-oic acid) containing oxo, hydroxyimine, and thiosemicarbazone groups were synthesized. Isosteviol 15-oxo-16-thiosemicarbazone forms a 1: 1 complex with Cu II and inhibits the growth of Mycobacterium tuberculosis (H37R V, in vitro) at the minimum inhibitory concentration of 20 μg mL −1. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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