Synthesis and study of new derivatives of 6-[methoxy(phenyl)methyl]-2-(nitroamino)pyrimidin-4(3H)-one.

Autor: Novakov, I. A., Orlinson, B. S., Kameneva, I. Yu., Zakharova, E. K., Nawrozkij, M. B.
Předmět:
Zdroj: Russian Chemical Bulletin; Jan2013, Vol. 62 Issue 1, p138-141, 4p
Abstrakt: New 6-[(2,6-dihalophenyl)(methoxy)methyl]-5-methyl-2-(nitroamino)pyrimidin-4(3 H)-ones were synthesized by an original and efficient method involving regioselective O,O′-dimethylation of substituted mandelic acids in superbasic medium. The compounds obtained can serve as precursors to a novel series of non-nucleoside HIV-1 replication inhibitors. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index