| Autor: |
Pruneri, Giancarlo, Bertolini, Francesco, Baldini, Luca, Valentini, Stefano, Goldaniga, Maria, Soligo, Davide, Carboni, Nadia, Viale, Giuseppe, Lambertenghi-Deliliers, Giorgio |
| Předmět: |
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| Zdroj: |
British Journal of Haematology; Feb2003, Vol. 120 Issue 4, p695-698, 4p |
| Abstrakt: |
Summary. Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti-CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non-obese diabetice/severe combined immunodeficient mice transplanted with the HCL line Bonna-12. The anti-CD105 Ab was significantly more sensitive than anti-CD34 Ab in identifying blood vessels. The BM tumour burden significantly decreased in patients treated with interferon-α, but the mean value of MVD remained unchanged. These data suggest that angiogenesis may be involved in the pathogenesis of HCL. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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