| Autor: |
Edenberg, Howard J., Reynolds, Jennifer, Koller, Daniel L, Begleiter, Henri, Bucholz, Kathleen K., Conneally, P. Michael, Crowe, Raymond, Goate, Alison, Hesselbrock, Victor, Li, T.-K., Numberger, John I., Porjesz, Bernice, Reich, Theodore, Rice, John P., Schuckit, Marc, Tischfield, Jay A., Foroud, Tatiana |
| Zdroj: |
Alcoholism: Clinical & Experimental Research; 1998, Vol. 22 Issue 5, p1080-1085, 6p |
| Abstrakt: |
A population association between a regulatory variation in the promoter of the serotonin transporter gene (HTT) and severe alcohol dependence was recently reported. We analyzed this potential association in a large number of systematically ascertained families in the United States; these families had at least three first-degree relatives who were alcohol-dependent. Analyses focused on individuals defined as alcohol-dependent by criteria from ICD-10 and on subsets of these individuals reporting withdrawal-related symptoms. Application of the transmission disequilibrium test did not provide support for either linkage or association between this functional polymorphism and alcohol dependence; there was no significant bias in the transmission of either allele to the alcohol-dependent offspring. We also report that African Americans differ from Caucasians in allele frequencies for this polymorphism. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
