| Autor: |
Pedersen, Knud L., Pedersen, Søren N., Christiansen, Lisette B., Korsgaard, Bodil, Bjerregaard, Poul |
| Zdroj: |
Pharmacology & Toxicology; 2000, Vol. 86 Issue 3, p110-113, 4p |
| Abstrakt: |
The widely used phenolic preservatives ethylparaben, propylparaben, butylparaben and their common metabolite p-hydroxybenzoic acid were tested for their ability to evoke an oestrogenic response in vivo. Yolk protein induction in sexually immature rainbow trout was used as an oestrogen-specific endpoint after repeated injections of the compounds. All tested parabens were oestrogenic in doses between 100 and 300 mg/kg, while the metabolite showed no activity. Ethylparaben was found to be approximately sixty times weaker than propyl- and butylparaben which had oestrogenic potencies comparable to those previously found for bisphenol A. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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