Effects of Propofol on Contractile Response and Electrophysiological Properties in Single Guinea-Pig Ventricular Myocyte.

Autor: Shigemura, Toshiaki, Hatakeyama, Noboru, Shibuya, Nobuko, Yamazaki, Mitsuaki, Masuda, Akira, Chen, Fu-Shih, Momose, Yasunori, Ito, Yusuke
Zdroj: Pharmacology & Toxicology; 1999, Vol. 85 Issue 5, p111-114, 4p
Abstrakt: Effects of propofol on contractile response, action potential, resting membrane potential and L-type voltage-dependent calcium channel current were examined in guinea-pig single cardiac myocyte. Propofol (10−4 M) inhibited contractile response induced by electrical stimulation (83.6% of control, n=5), but did not change the resting membrane potential. On the other hand, propofol reduced the overshoot of action potential (10−4 M), and shortened the duration of action potential (10−5 and 10−4 M). Whole-cell voltage clamp experiment showed inhibition of L-type calcium channel current (ICa, 10−5 M: 90.8+1.39, 10−4 M: 83.4+1.53% of control, n=5). In addition, propofol showed use-dependent block of ICa. It is concluded that negative inotropic effect of propofol is caused by suppression of action potential, and that inhibition of ICa plays a role in shortening of the duration of action potential. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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