| Autor: |
Chugh, Yati, Saha, N., Sankaranarayanan, A., Datta, H. |
| Zdroj: |
Pharmacology & Toxicology; 1991, Vol. 69 Issue 2, p105-106, 2p |
| Abstrakt: |
Experimental evidence suggests an important role of serotonin in the process of learning and memory. The present study investigated the effect of 5HT3-receptor antagonist (ICS 205-930) on retrieval of a previously learned aversive habit in the mouse. The effect of ICS 205-930 on scopolamine (3 mg/kg) induced amnesia was also studied. ICS 205-930 (1, 10 & 100 μg/kg) produced a dose-dependent increase in latency to cross into the dark chamber. The scopolamine induced memory impairment was significantly attenuated by ICS 205-930 (10 μg/kg). These results suggest that memory deficits may be susceptible to attenuation with non-cholinergic treatments. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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