| Autor: |
Hall, Kirsten Sundby, Endresen, Liv, Rugstad, Hans Erik |
| Zdroj: |
Pharmacology & Toxicology; 1990, Vol. 67 Issue 5, p402-405, 4p |
| Abstrakt: |
We have examined the influence of verapamil (VP) on the in vitro effect of 4′-epidoxorubicin (Epi-A) in a rat hepatocarcinoma cell line (MH1C1) and in an Epi-A resistant substrain. A VP concentration of 500 ng/ml (1.1 μmol/l) markedly potentiated the cytotoxic effect of Epi-A in the parent line. The resistant cells grow at an Epi-A concentration of 7500 ng/ml (12.9 μmol/l). This is approximately 15-fold higher than the concentration tolerated by parental cells. In these cells VP reversed the acquired resistance to Epi-A in a concentration dependent manner; thus, a concentration in the range of 500-750 ng/ml (1.1-1.7 μmol/l) of VP restored the sensitivity to Epi-A in the resistant cells. Our results demonstrate that VP increases the sensitivity to Epi-A in hepatocarcinoma cells never exposed to this drug, as well as in hepatocarcinoma cells with acquired Epi-A resistance. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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