Comparative properties of N-acetyl derivatives of oxime N-methylcarbamates and aryl N-methylcarbamates as insecticides and acetylcholinesterase inhibitors.

Autor:	Boulton, J. J. K., Boyce, C. B. C., Jewess, P. J., Jones, R. F.
Zdroj:	Pesticide Science; 1971, Vol. 2 Issue 1, p10-15, 6p
Abstrakt:	N-acylation of aryl N-methylcarbamates is known to reduce their mammalian toxicity considerably without adversely affecting their insecticidal activity. It has now been found that N-acylation of several insecticidal oxime carbamates results in loss of toxicity both to insects and mammals. Kinetic data for base-catalysed solvolysis and inhibition of acetylcholinesterase, together with published work on metabolism, are combined to provide a rationale for this unexpected observation and to account for the selective toxicity of aryl N-acetyl- N-methylcarbamates. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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