| Autor: |
Magueur, E., Hagege, H., Attali, P., Singlas, E., Etienne, JP, Taburet, AM |
| Zdroj: |
British Journal of Clinical Pharmacology; 1991, Vol. 31 Issue 2, p185-187, 3p |
| Abstrakt: |
The pharmacokinetics of metoclopramide were investigated after intravenous and oral administration in eight patients with severe alcoholic cirrhosis and in eight healthy volunteers. As a consequence of a 50% lower clearance (0.16 +/- 0.07 vs 0.34 +/- 0.09 l h-1 kg-1, plasma drug concentrations and the half-life of metoclopramide were greater in patients following both routes of drug administration. Volume of distribution (3.1 +/- 0.8 vs 3.4 +/- 1.2 l kg-1) and absolute bioavailability (79 +/- 19 vs 84 +/- 15%) were similar in the two groups. The adverse effects of metoclopramide observed in patients with marked hepatic impairment are likely to result from increased accumulation of the drug as a result of impaired clearance. Consequently a reduction in dose of 50% is recommended in patients with severe liver cirrhosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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